The study examines the impact of intermittent pneumatic Compression (IPC) on coagulation, fibrinolysis, and deep vein thrombosis (DVT) in Chinese patients with benign gynecological conditions undergoing minimal invasive gynecological surgery. The primary outcomes assessed for coagulation blood tests include prothrombin time (PT), international normalized ratio (INR), percentage of prothrombin time (PT%), activated partial thromboplastin time (APTT), plasma fibrinogen (FIB), plasma D-dimer (D-D), and fibrinogen degradation products (FDP) and the rate of DVT incidence. The study was conducted at the Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, between January 2021 and August 2022. The study was approved by the Ethics Committee of Guangdong Provincial Hospital of Chinese Medicine. Cases were identified by searching the hospital’s Electronic Discharge Database, and a comprehensive review of medical documentation was conducted to collect relevant data. The study included Chinese adult female patients from Guangdong province with a diagnosis of benign gynecological disease (uterine fibroid or ovarian cysts) who had indications for gynecological laparoscopic surgery. The exclusion criteria included a history of thrombotic disease, leg ulcer, and peripheral vascular disease before admission, blood coagulation disorders, malignant gynecological tumors or cancer treatment, anticoagulant use, smoking, recent long travel, acute medical illness, recent surgery, and lack of civil capacity. The patients who received standard minimally invasive gynecological surgery were recorded, and the patients were divided into a Device group and a Non-device group based on the patients applied with or without IPC during intraoperative and perioperative nursing care. The Phlebo Press® DVT device was applied on the lower limbs, delivering the standard of pneumatic compression therapy with circumferential, sequential, gradient compression by following the manufacturer's instructions. Bilateral calf-ankle mechanical pneumatic compression started intraoperatively and was continuously monitored for half an hour postoperatively in the recovery room. Anti-thromboembolism stockings were not applied for the patients in order to exclusively examine the effect of the mechanical compression method. The study aimed to evaluate the impact of mechanical compression on coagulation and fibrinolysis and the occurrence of DVT in Chinese patients with benign gynecological conditions undergoing minimal invasive gynecological surgery.
